NFL

49ers vs Seahawks Predictions, Picks & Best Bets for Today — NFC Divisional Round


The Seattle Seahawks have the makings of a Super Bowl contender, but their postseason ceiling may finally hinge on quarterback Sam Darnold tonight.

Darnold cooled off late in the season, and his playoff history raises questions about whether he can make it on the biggest stage. The San Francisco 49ers are well aware of that uncertainty and will look to make Darnold the deciding factor in Saturday’s Divisional Round game.

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I predict a lot of passes to the Travelman QB, which gives me strength 49ers vs. Seahawks predictions and NFL picks on Saturday, January 19.

49ers vs Seahawks prediction

49ers vs Seahawks Best Bet: Sam Darnold Over completions 19.5 (-102)

Sam Darnold completed 20 of 26 passes in a win over the San Francisco 49ers in Week 18, when the Seattle Seahawks had a tough time.

The Niners they showed they can be tough on the floor in the second half of their wild card win in philadelphia, and they will sell to stop seattle’s chase. to attack. That leaves Darnold a big step back.

He has completed 20+ passes in four of his last five games and faces a 49ers defense that doesn’t generate pressure and allows the fifth-highest completion rate. His projection ranged from 19.8 to a ceiling of 22 completions in the game.

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49ers vs Seahawks for the same game

A rested and fit Seattle team got a big boost when the schedule forced the Niners to take a short week to play on Saturday.

Darnold will get plenty of dropbacks and a chance to prove his worth against a passive 49ers defense. His projection consistently averaged 257 passing yards. Jaxon Smith-Njigba is Darnold’s top target and has 7+ points in 12 of his 17 games this season.

49ers vs Seahawks SGP

  • Sam Darnold Over 237.5 passing yards

  • Jaxon Smith-Njigba Over 6.5 receptions

Our big-ticket SGP: The best in the Pacific Northwest!

In a battle between the two front-runners for Offensive Player of the Year, JSN sees plenty of touchdowns and torches for the Niners’ secondary that is soft for touchdowns.

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With San Francisco on the back foot, Christian McCaffrey stepped up as a receiver and kept the touchdowns coming after scoring twice in Philly.

49ers vs Seahawks SGP

  • Jaxson Smith-Njigba whenever he is contacted

  • Jaxson Smith-Njigba Over 6.5 receptions

  • Christian McCaffrey for any touchdown

  • Christian McCaffrey Over 6.5 receptions

49ers vs Seahawks game predictions

49ers vs Seahawks money line prediction

The exact price in Seattle is a sweet ask for a reason. Seattle is healthy and beat this Niners team the last time they took the field.

San Francisco continues to battle injuries and now heads to Lumen Field on a short week.

49ers vs Seahawks distribution prediction

The spread jumped all the way to Seattle -7.5 before being bought back in San Francisco.

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I can see the appeal for scoring more points, given how good the 49ers looked last weekend and the familiarity — which breeds rivalry — between these two NFC West foes.

49ers vs Seahawks Over/Under prediction

My first bet of the week was under 47.5 for this game, and this number has dropped since then, down to 44.5 points.

Points will be at a premium, as they often are in the postseason, but tread lightly on any late Under bets as you are far from the no.

49ers vs Seahawks odds

  • Spreading: 49ers +7.5 (-110) | Seahawks -7.5 (-110)

  • Moneyline: 49ers +280 | Seahawks -360

  • Above/Below: Over 45 (-110) | Under 45 (-110)

Lots of NFL picks and odds on Covers

49ers vs Seahawks trend to know

Since becoming Seattle’s head coach, Mike Macdonald is 8-4 SU, 7-5 ATS, and owns a 5-7 O/U record against NFC West opponents. Find more NFL betting trends for 49ers vs. Seahawks.

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How to watch 49ers vs Seahawks

Location

Lumen Field, Seattle, WA

The day

Saturday, January 17, 2026

Getting started

8:00 pm ET

The TV

THE CONCENTRATION

49ers vs Seahawks latest injury

49ers vs Seahawks weather

Monitor game-time conditions with our live NFL weather information and learn how weather affects NFL betting.

Odds are correct at press time and subject to change.
Not intended for use in MA.
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