NFL

Seahawks vs. 49ers odds, picks, predictions: The best NFL division game bets

ballervisions 2026年1月16日

Seahawks vs. 49ers odds, picks, predictions: The best NFL division game bets

The NFC West champion and No. 1 seed Seattle Seahawks will host the San Francisco 49ers on Saturday in the third meeting between the two teams this season. The Seahawks beat the 49ers 13-3 in Week 18 to clinch the NFC West and the conference’s top seed, so they rested at home while San Francisco went on a dramatic comeback and beat the Philadelphia Eagles 23-19 as a 5.5-point underdog.

Can Kyle Shanahan win another game as an underdog? Will Sam Darnold overcome his struggles in the big games to lead Seattle to the NFC championship game?

Here are the details from the game designers, and our team of NFL handicappers provide their favorite wagers on the game.

Odds courtesy of BetMGM.

What the oddsmakers say

“I put the 49ers on my Christmas list for next year after they eliminated the Eagles from us. The loss of George Kittle is huge, as they were basically a MASH unit all season. We opened Seattle -6.5, it was quickly bet to -7 and touched -7.5. Now we’re back down to -7. Great two-way action. Action 46 down from Sharp 45. Total down. Seattle is our best case for the future, both the Super Bowl and the NFC, and the 49ers aren’t bad. The only team we owe is the Rams. – Thomas Gable, sports book director at The Borgata

[Yahoo Sports TV is here! Watch live shows and highlights 24/7]

“Last week, we saw an unprecedented move with punters betting the Eagles from -3.5 to 6 before others brought it back to -5.5. The thought was that the 49ers were beaten and there would be some weather and they couldn’t compete – and that wasn’t the case. We opened this game at Seahawks -7, we hit it short at 7.5 Seers and now we’re putting a lot of money back at 7.5, 4 Seers. covering +7.5 is the biggest number for a division game.” – Joey Feazel, head of NFL trading at Caesars Sportsbook

A very good bet

Matt Jacob: Total points scored when the Seahawks and 49ers squared off for the second time last season: 37.

Total points scored when these NFC West rivals meet in the 2025 season opener in Seattle: 30.

Total points scored in the 2025 regular season finale in San Francisco: 16.

In fact, seven of the last nine head-to-head meetings have been by a combined 45 points.

Yes, the Niners’ defense has been disjointed at times this season – from Weeks 15-17, they gave up 89 points to Caleb Williams, Philip Rivers and Cam Ward. But that defense stepped up for the Super Bowl defense last week and did it on the road.

And in two games against the Seahawks, San Francisco has given up just two touchdowns and four field goals.

During that time, Seattle had the NFL’s No. 1 scoring defense in the regular season, allowing just 17.2 points per game. In addition, if you take a 38-37 wild win in overtime over the explosive Rams, here are the total points produced by Seattle’s last four visitors: 19 (Texans), 22 (Cardinals), 0 (Vikings) and 16 (Colts).

Bet: Under 45 total points (-110)

Russell: The part and parcel and the under is that the No. 1 task for the Seahawks is to manage Darnold’s exposure to potential turnovers, because producing more interceptions or taking away a quarterback sack is the only way the 49ers can win this game.

Usually, the team that won the last matchup has to worry about having to make some changes to stay ahead of the changes the losing team will make, but Seattle’s Week 18 performance was so basic that it can’t replicate its success down the stretch. After all, it wasn’t surprising that San Francisco would be cut down, as the Bears ran well last week, and Saquon Barkley had a rare 100-yard game this season in a wild-card game, a week after Seattle’s tailback duo combined for 171 yards on 33 carries in Week 18.

Which means the running back will erase the totality of his various props is difficult to determine, so we will bet that Darnold is not asked to do much, and that the 49ers defense will continue its plan to keep everything in front of it, hoping to stop it in the red zone. In an unnecessary and unexpected outburst, we’ll blur Darnold’s yardage totals, with a grudging compliment about the Seahawks’ chances of victory.

Bet: Sam Darnold under 236.5 passing yards (-115)

Jacob: Two weeks ago against the Seahawks, Christian McCaffrey touched the pigskin 17 times and produced a total of 57 scrimmage yards. Not only was McCaffrey playing at home, but his 49ers teammate (and Pro Bowler) George Kittle was on the field drawing the attention of the Seahawks linebackers and defensive backs.

This week, McCaffrey goes to Seattle and Kittle won’t be around the field after tearing his Achilles last week in Philadelphia. In other words, CMC will be public enemy No. 1 (and No. 2 and 3) on Seattle’s best defense.

Of course, McCaffrey will get plenty of opportunities to repeat last week’s performance in Philadelphia (21 touches, 114 total yards). Not just because of his dual-threat skills, but also because 49ers quarterback Brock Purdy doesn’t have a ton of other options.

Still, even if McCaffrey gets his hands on the ball 25 times, you can really see him to double the numbers he produced against Seattle in Week 18? Especially against a defense whose rallying cry this week should be “Anyone but McCaffrey?”

Of course I can’t.

Bet: Christian McCaffrey under 107.5 rushing and receiving yards (-105)

Feng: Purdy has been very good this season. If I take his yards per pass attempt and adjust for opposing defenses, Purdy is expected to throw a 6.95 YPPA against an average NFL defense, fifth-best among starters. However, he is facing an elite Seattle defense that ranks third in those same numbers. My adjusted YPPA based model predicts 219 passing yards for Purdy, and it should be less even without Kittle and probably WR Ricky Pearsall.

Purdy was without both receivers last week — Kittle was injured on his second target — but still threw for 262 yards against Philadelphia’s best defense. That performance probably raises this number.

Bet: Brock Purdy under 229.5 passing yards